Diabetic Ketoacidosis

DIABETIC ketoacidosis INTRODUCTION diabetic ketoacidosis (DKA) is a very serious tortuosity of diabetes mellitus, a metabolic disorder that is characterized by hyperglycemia, metabolic acidosis, and increased body ketone concentrations. The almost rough-cut suit of clothess of DKA atomic number 18 infection and poor compliance with medicine regimens. Other bms allow in undiagnosed diabetes, alcohol abuse, and a multitude of medical examination conditions such as cerebrovascular accident (CVA), complicated pregnancy, myocardial infarction, pancreatitis, and stress. diabetic ketoacidosis is a complicated pathology.Early recognition of DKA, a good reasonableness of the pathological processes of DKA, and aggressive word ar the keys to successful discussion. With good fretting, DKA turn back nonice be man come ond and the longanimous will survive. OBJECTIVES When the student has finished studying this module, he/she will be able to 1. expose the change by reversal d efinition of DKA. 2. detect a elemental function of insulin. 3. attain the insulin derangements of types I and II diabetes. 4. Identify the basic shit of DKA. 5. Identify deuce specific causes of DKA. 6. Identify the ii pathogenic mechanisms that produce the signs/symptoms of DKA. . Identify metabolic consequences of increased internal secretion concentrations in DKA. 8. Identify the criteria used to diagnose DKA. 9. Identify common signs and symptoms of DKA. 10. Identify science laboratory ab naturalities seen in DKA. 11. Identify torsions of DKA. 12. Identify the three most weighty therapies for treating DKA. 13. Identify the correct roles of atomic number 11 bicarbonate and inorganic phosphate in treating DKA. 14. Identify an alpha rule for using green replacement in DKA. 15. Identify an important rule for switching from IV to subcutaneous insulin.EPIDEMIOLOGY Most themes of DKA be seen in long-sufferings with type I diabetes, but approximately 10%-30% of all ca ses of DKA add up in tolerants with type II diabetes. 1 The incidence of DKA appears to be rising, and this may non be related to the well realityized increase in the incidence of diabetes that has become a serious public health problem. 2 diabetic ketoacidosis accounts for 50% of all diabetes-related admissions in young peck with the disease, and DKA is the most common cause of diabetes-related death in children and adolescents with type I diabetes. diabetic ketoacidosis is much more common in children than in adults, it is more common in women than in men, and it is more common in Caucasians. 4 The exact incidence of death from DKA is not known, but it has been estimated to be between 1%-10%. 5 Survival depends on the severity of the case, the age of the patient, the presence/absence of certain medical conditions, and how quickly DKA is recognized and how effectively it is treated. If the condition is promptly diagnosed and properly treated, the mortality number contribu te be 250 mg/dL) metabolic acidosis ( rail line pH ? . 30) and an lofty aim of blood serum ketones ( 5 milliequivalent/L) and/or ketones in the urine. 11 Patients will also gravel an anion gap (Na+ Cl- + HCO3-), an elevated blood urea nitrogen (BUN), hyponatremia, hyperkalemia, and the serum amylase may be elevated. The heart body phosphate sell aim may be low but the serum level may be normal or elevated. At this time, in that respect is no universally agreed upon consensus for the diagnostic criteria of DKA, and some sources feel that an anion gap 10-12 milliequivalent/L and serum bicarbonate (HCO3) ? 8 mEq/L should be part of the criteria. knowledge recess Some authors feel that most important test for diagnosing DKA is tot blood ketone concentration. 12,13 The acidosis and hyperglycemia of DKA and the electrolyte changes that are so commonly seen in DKA are intimately related. The shift in metabolism and the uplifted concentration of acidulent ketones seen in c ases of DKA produces a metabolic acidosis. Acidosis and insulin deficiency causes kilobyte to shift from the intracellular quad to the extracellular space and serum hyperkalemia is common.However, the osmotic diuresis that is characteristic of DKA causes potassium to be excreted in the urine although the serum potassium level may be high, the patient may be profoundly depleted. Sodium and phosphate are also excreted by the osmotic diuresis, and hyponatremia is common. However, the serum phosphate level is often falsely normal or falsely elevated because phosphate, comparable potassium, is excreted in the urine but acidosis induces phosphate to scarper from the intracellular space to the extracellular space.The serum level dexterity be normal, but the real(a) total body load is low. Learning Break The serum glucose female genitals be very elevated in unspeakable cases of DKA. However, serum glucose potentiometer be nasty to normal, and approximately 10% of patients with DKA will be euglycemic with a serum glucose ? 250 mg/dL. 14 COMPLICATIONS OF DIABETIC KETOACIDOSIS Patients who learn diabetic ketoacidosis that is promptly recognized and promptly and correctly treated should survive. The complications of DKA are complications of treatment and cerebral edema.Treatment complications are hypoglycemia, hyperkalemia, and occasionally pulmonary edema. These heap be avoided by using low-dose insulin therapy, monitoring blood glucose very closely, and by guardedly managing fluid replacement. Cerebral edema is a very serious complication of DKA. It occurs in approximately 1% of all children with DKA, but the mortality rate and the rate of neurological sequelae for these children take on both been reported to be 21%, and the mortality rate and rate of sequelae can be as high as 24% and 26% respectively15,16 Adults with DKA rarely develop cerebral edema. 7 Signs and symptoms include mental status changes, bradycardia, seizures, abnormal response to pain, a nd decorticate and decerebrate posturing. discussion FOR DIABETIC KETOACIDOSIS The most important treatments for DKA are fluid replacement, insulin therapy, and correcting electrolyte balances. dumbfound baseline serum electrolytes, BUN, creatinine, serum glucose, an arterial or venous blood gas (either one is appropriate), a complete blood count, an ECG, and a CXR. fill other laboratory studies if DKA is thought to be caused by an underlying disease. runny replacement still replacement will replace the fluid deficit, facilitate reduce the blood glucose level, and maintain renal function. If the patient is severely hypovolemic, devolve 1 liter of 0. 9% sodium chloride over 30 minutes. If the patient is mildly dehydrated, check the serum sodium. If it is normal or high, extend to 0. 45% sodium chloride IV at a rate of 250-500 mL/h. If the serum sodium is low, give 0. 9% sodium chloride IV at a rate of 15-20 mL/kg per hour. in one case the blood glucose is approximately 2 h undred mg/dL, a solution of % dextrose with 0. 45% sodium chloride can be used. 18Learning Break In the first hour of treating a patient with DKA, fluid replacement is more important than insulin therapy and should take precedent. 19,20 Insulin therapy Insulin is a vital part perhaps the critical part of the treatment of DKA. It can be given as an IV selection or frequent subcutaneous injections they are equally effective. Most clinicians prefer the IV route as the trespass of action is quicker and the half-life is shorter with the IV route than the on tick off of action of and half-life of insulin given subcutaneously because of that, therapy can be closely monitored.The American Diabetes Association recommends giving an initial IV bolus of regular insulin, 0. 1 U/kg. (Note If the serum potassium is 3. 3 mEq/L insulin should not be given). Following the bolus dose, start a continuous IV infusion of regular insulin at a rate of 0. 1 U/kg/h. An alternative is to omit the bolus dose and start a continuous IV infusion of regular insulin at a rate of 0. 14 U/kg/h. If the serum glucose does not decrease by 10% at bottom an hour of starting the insulin, give 0. 14 U/kg as a bolus dose, then continue the IV infusion.Once the serum glucose is 200 mg/dL, reduce the insulin dose to 0. 02-0. 05 U/kg/h or give subcutaneous doses of rapid-acting insulin, 0. 1 U/kg both two hours. The finish at this point is to keep the serum glucose between 150-200 mg/dL. 21 0. 1 U/kg IV bolus v 0. 1 U/kg/hr * v When serum glucose 200 mg/dL, decrease infusion to 0. 02-0. 05 U/kg/h v Keep serum glucose between 150-200 mg/dL until DKA resolves * If serum glucose doesnt v by at least 10% in the 1st hour of insulin therapy, give an IV bolus of 0. 14 U/kg and adjust the infusion. Correcting electrolyte imbalances If the serum potassium is 3. 3 mEq/L, do not start insulin therapy and give 20-30 mEq of potassium per hour until the serum level is 3. 3 mEq/L. Fluid replacement and insul in therapy lower blood sugar and correct acidosis and they also move potassium into the cells. If the serum potassium is 3. 3 mEq/L, serious arrhythmias could result. Once the hypokalemia has been corrected, insulin therapy can be started, and 20-30 mEq of potassium can be added to severally liter of IV solution in order to maintain a serum potassium level between 4. -5. 0 mEq/L. Learning Break Serum glucose and serum potassium should be checked every hour until the patient is stable. Two other considerations for treatment are administering sodium bicarbonate to help correct the acidosis and replacing phosphate losses. Using sodium bicarbonate is controversial. Severe acidosis can decrease myocardial contractility, can cause and prolong coma, shifts the oxyhemoglobin dissociation curve to the right, etc. , so correcting an acidosis would consider the appearance _or_ semblance important. However, there are risks involved (e. g. making body hypokalemia worse, cerebral edema), ther e are galore(postnominal) clinical studies that indicate sodium bicarbonate therapy is not effective for patients with DKA, and for many patients the acidosis will correct with fluids and insulin and because they cede adequate stores of bicarbonate. 22 The use of sodium bicarbonate should not be shopworn take for DKA. However, the American Diabetes Association does recommend that if a patient has a severe acidosis with a pH 6. 9, the patent should receive 100 mEq of NaHCO3 in 400 mL IV fluid along with 20 mEq of potassium chloride this should be infused at 200 mL/h.Repeat this every two hours until the pH is ? 7. 0. 23 Low phosphate levels will usually correct as the hyperglycemia and acidosis are corrected, and phosphate replacement is not standard care for DKA. However, if the phosphate is very low 1. 0 mg/dL or the patient has anemia, cardiac disease, or hypoxia, 20-30 mEq of phosphate can be given. 24,25 SWITCHING TO SUBCUTANEOUS INSULIN diabetic ketoacidosis is consider ed to be contumacious when the blood glucose is 200 mg/dL and at least two of these laboratory values are present a venous pH 7. 3, an anion gap 12 mEq/L, and a serum bicarbonate level 15. mEq/L. 26 If these laboratory values are present and the patient can eat, it is safe to start subcutaneous insulin. Intravenous insulin should be keep for one to two hours after the first dose of subcutaneous insulin has been given. If this is not done, hyperglycemia and ketosis may recur. NURSING CARE, PREVENTION AND EDUCATION When providing care for a patient in the acute phase of DKA, the reserve should think on hydration status/fluid replacement, monitoring of acid-base status, serum glucose, and serum electrolytes, close observation of the patients neurological status, and vital signs.Once a case of DKA has resolved it is important to know why it kick downstairsed. Infections, medical conditions, and drugs are common causes of DKA. However, one of the most important causes of DKA is patient non-compliance with diabetic treatment regimens patients do not take their medication or do not take them properly, they fail to follow their prescribed diet and lifestyle plans, and they do not or cannot understand the basics of self-care and prevention as they relate to diabetes.If non-compliance was the cause of a particular case of DKA, it is very important to determine why the non-compliance occurred, and there many possible reasons. Some of the more common ones are Poor access to medical care The patient may not have access to health care information, may not have easy access to a physician, clinic, etc. , may not have or not know how to use community or public access health care resources. The patient may not have money for medications. Lack of information The patient may have a poor understanding of diabetes, and the patient may not understand the treatment regimens that have been prescribed. Lack of information can be damaging in many ways. If the patient doesnt un derstand the disease of diabetes, he/she might be little unforced to comply with lifestyle and diet restrictions and less willing to take medications. The patient would not recognize possible admonishment signals of DKA. Emotional issues For many people, diabetes requires lifestyle changes that they may not be willing to arousedly accept.Learning Break Although it may be said that non-compliance happens when the patient fails to furnish good self-care, the word fail typically has a negative connotation. Also, when many people hear the term non-compliance, they think of a soul willfully failing to do what he/she knows is best. However, there are many cases of non-compliance that happen because the patient has not been properly educated, or doesnt have or doesnt know how to get the resources he/she needs.So when it has been determined that non-compliance was the cause of a particular case of DKA, interview the patient and find out a) the emotional impact of diabetes on the pat ients life, b) how much he/she knows about the disease and the treatments, and c) what financial, medical, personal, and social resources the patient has available for self-treatment. Some of these issues must be addressed by social workers, psychologists, or the patients physician. However, nurses have a primary role in supporting and educating patients who have had an casualty of DKA related to on-compliance. The nurse will often be the first person to find out that the patient did not seek medical direction for an infection because of financial concerns, or due to inability to each a physician, or because of a lack of understanding of the implications of infection in diabetes. The nurse must then discuss making the appropriate referrals and then set up a teaching plan. Some of the nursing diagnoses that might collapse in theses situations would be imbalanced nutrition, noncompliance, knowledge deficient, and risk for injury. SUMMARY Diabetic ketoacidosis is a metabolic disorde r characterized by hyperglycemia, metabolic acidosis, and elevated body ketone concentrations. The basic cause of DKA is insulin deficiency, absolute or relative. The insulin deficiency most often occurs because of infection or non-compliance with diabetic treatment regimens. Excess hormone concentration and a metabolic shift are the pathogenic mechanisms that cause the signs and symptoms of DKA. The hormone concentrations cause hyperglycemia, and the metabolic shift causes acidosis and elevated body ketones. The basic diagnostic criteria for DKA are a blood glucose 250 mg/dL, a serum pH 7. 3, and elevated serum and/or urine ketone concentrations. Other important criteria are an anion gap 10-12 mEq/L and serum bicarbonate (HCO3) ? 18 mEq/L. Hyperkalemia and hyponatremia are common in DKA. Hypophosphatemia can be seen. However, the total body load of potassium and phosphate is often low. Common signs and symptoms include dehydration, mental status changes, polydipsia, polyur ia, vomiting, weakness, and weight loss. Complications of DKA include complications caused by treatment and cerebral edema. Treatment for DKA should focus on fluid replacement, insulin therapy, and correcting electrolyte abnormalities. Sodium bicarbonate is not standard care. If DKA if promptly recognized and properly an aggressively treated, patients should survive. REFERENCES 1. Wilson JF. In the clinic Diabetic ketoacidosis. Annals of inseparable Medicine. 2010 152ITC-1-ITC-16. 2. Kitabchi AE, Umpierrez GE, Miles JM, fisher JN. Hyperglycemic crises in adult patients with diabetes. Diabetes Care. 2009321335-1343. 3. Wolfsdorf J, Glaser N, Sperling MA.Diabetic ketoacidosis in infants, children, and adolescents a consensus arguing from the American Diabetes Association. Diabetes Care. 2006291150-1159. 4. Hamdy O. Diabetic ketoacidosis. eMedicine. family line 9, 2009. on hand(predicate) at http//emedicine. medscape. com/ hold/118361. Accessed December 24, 2010. 5. Hamdy O. Diab etic ketoacidosis. eMedicine. September 9, 2009. Available at http//emedicine. medscape. com/article/118361. Accessed December 24, 2010, 6. Kitabchi AE, Umpierrez GE, Miles JM, fisherman JN. Hyperglycemic crises in adult patients with diabetes. Diabetes Care. 2009321335-1343. . Rucker DW. Diabetic ketoacidosis. eMedicine. June 4, 2010. Available at http//emedcine. medscape. com/article/766275. 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Kitabchi AE, Umpierrez GE, Miles JM, Fisher JN. Hyperglycemic crises in adult patients with diabetes. Diabetes Care. 2009321335-1343. 22. Kitabchi AE, Umpierrez GE, Miles JM, Fisher JN. Hyperglycemic crises in adult patients with diabetes. Diabetes Care. 2009321335-1343. 23.Wilson JF. In the clinic Diabetic ketoacidosis. Annals of Internal Medicine. 2010 152ITC-1-ITC-16. 24. Kitabchi AE, Umpierrez GE, Fisher JN, Murphy NB, Stentz FB. Thirty years of personal experience in hyperglycemic crises diabetic ketoacidosis and hyperglycemic hyperosmolar state. Journal of Clinical Endocrinology & Metabolism. 2008931541-1552. 25. Wilson JF. In the clinic Diabetic ketoacidosis. Annals of Internal Medicine. 2010 152ITC-1-ITC-16. 26. Kitabchi AE, Umpierrez GE, Miles JM, Fisher JN. Hyperglycemic crises in adult patients with diabetes. Diabetes Care. 2009321335-1343.